Correlation between Helicobacter pylori infection, gastric diseases and life habits among patients treated at a university hospital in Southeast Brazil
| Autor: | José Luiz Pimenta Módena, André Fernando Ditondo Micas, Ricardo Brandt de Oliveira, Marly de Castro, Wanderley Dias da Silveira, José Luiz Proença Módena, Gustavo Olszanski Acrani, Marcelo Brocchi |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.medical_specialty Adolescent Peptic lcsh:QR1-502 Stomach Diseases Disease life habits Gastroenterology lcsh:Microbiology lcsh:Infectious and parasitic diseases Helicobacter Infections Hospitals University Risk Factors Internal medicine Genotype medicine Ingestion Humans lcsh:RC109-216 Child Life Style Aged Retrospective Studies Aged 80 and over biology Helicobacter pylori business.industry gastric ulcer gastritis Intestinal metaplasia Middle Aged biology.organism_classification medicine.disease Infectious Diseases Logistic Models GERD Female duodenal ulcer Gastritis medicine.symptom business Brazil |
| Zdroj: | Brazilian Journal of Infectious Diseases v.11 n.1 2007 Brazilian Journal of Infectious Diseases Brazilian Society of Infectious Diseases (BSID) instacron:BSID ResearcherID Brazilian Journal of Infectious Diseases, Vol 11, Iss 1, Pp 89-95 Brazilian Journal of Infectious Diseases, Volume: 11, Issue: 1, Pages: 89-95, Published: FEB 2007 |
| Popis: | Helicobacter pylori is considered a significant agent in the development of various gastric diseases. However, the diseases caused by this bacterium are known as being multi-factorial, with the genotype, immune system and life habits of the host playing important roles in the establishment of the clinical outcome. Also, H. pylori exhibit a high degree of genetic variability, contributing to the complexity of the host-pathogen relationship. These observations, considered together with the widely-varying origins and social habits of the Brazilian population, lead us to speculate about the influence of these life habits on H. pylori infection and the clinical outcome. Therefore, in this study we evaluated the relationship between H. pylori infection and certain diseases in 172 patients treated at the Hospital das Clínicas of Ribeirão Preto (HCRP), Brazil, taking into account their different life habits, such as non-steroidal anti-inflammatory drugs and alcohol ingestion, and smoking habit. Our analysis indicated that H. pylori infection is not affected by any of the life habits evaluated but is associated with the development of peptic ulcers (gastric and duodenal ulcer) and inverse correlate with gastroesophageal reflux disease (GERD). No correlation was found between the infection with this bacterium and gastritis or intestinal metaplasia. However, gastritis and erosive gastritis were directly correlated with non-steroidal anti-inflammatory drugs (NSAID) ingestion. Moreover, ingestion of alcohol beverages exhibited a protective effect on gastritis development in men. Our data also indicated that to achieve reliable detection of this bacterium in biopsies, two or three detection methods should be used. |
| Databáze: | OpenAIRE |
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