Low circulating 25-hydroxyvitamin D level is associated with increased colorectal cancer mortality: a systematic review and dose–response meta-analysis
| Autor: | Mei Xue, Yongjie Zhao, Youkui Han, Guanghai Wu, Judong Zhang, Shuai Zhang, Chao Li, Jing Xu |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Colorectal cancer Biophysics colorectal cancer Biochemistry Gastroenterology Risk Assessment 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Epidemiology medicine Overall survival Humans Stage (cooking) Vitamin D Molecular Biology Diagnostics & Biomarkers Research Articles Cancer business.industry Hazard ratio Cell Biology medicine.disease vitamins Vitamin D Deficiency Confidence interval 030104 developmental biology Metabolism Sample size determination 030220 oncology & carcinogenesis Meta-analysis prognosis business Colorectal Neoplasms meta analysis |
| Zdroj: | Bioscience Reports |
| ISSN: | 1573-4935 0144-8463 |
| Popis: | Epidemiological studies have suggested inconclusive associations between 25-hydroxyvitamin D (25(OH)D) and survival in patients with colorectal cancer (CRC). The aim of the present study was to quantitatively assess these associations. PubMed, EMBASE, and Web of Science databases were systematically searched for eligible studies. Subgroup analyses based on study geographic location, publication year, length of follow-up time, sample size, and stage were conducted to explore the potential sources of heterogeneity. Dose–response relationships and pooled hazard ratios (HR) for overall and CRC-specific survival comparing the highest versus the lowest categories of circulating 25(OH)D concentrations were assessed. Overall, 17 original studies with a total of 17,770 CRC patients were included. Pooled HR (95% confidence intervals) comparing highest versus lowest categories were 0.64 (0.55–0.72) and 0.65 (0.56–0.73) for overall and CRC-specific survival, respectively. Studies conducted in the U.S.A., with median follow-up time ≥ 8 years, larger sample size, and including stage I-III patients showed a more prominent association between 25(OH)D concentrations and overall survival. The dose–response analysis showed that the risk of all-cause mortality was reduced by 7% (HR = 0.93; 95% CI: 0.90, 0.95), and the risk of CRC-specific mortality was reduced by 12% (HR = 0.88; 95% CI: 0.84, 0.93) for each 20 nmol/l increment of 25(OH)D concentration. This meta-analysis provides evidences that a higher 25(OH)D concentration is associated with lower overall mortality and CRC-specific mortality. |
| Databáze: | OpenAIRE |
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