Numerical analysis of micro- and nano-particle deposition in a realistic human upper airway
| Autor: | Pejman Farhadi Ghalati, Abolhassan Faramarzi, Erfan Keshavarzian, Jiyuan Tu, Alireza Shakibafard, Omid Abouali |
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| Rok vydání: | 2012 |
| Předmět: |
Nasal cavity
Materials science Respiratory System Nanoparticle Health Informatics Computational fluid dynamics Models Biological Young Adult otorhinolaryngologic diseases medicine Humans Deposition (phase transition) Computer Simulation Particle Size Aerosols Models Statistical business.industry Numerical analysis Computational Biology Mechanics Anatomy respiratory system Computer Science Applications medicine.anatomical_structure Inhalation Hydrodynamics Nanoparticles Female Tomography Particle size Tomography X-Ray Computed business Particle deposition |
| Zdroj: | Computers in Biology and Medicine. 42:39-49 |
| ISSN: | 0010-4825 |
| DOI: | 10.1016/j.compbiomed.2011.10.005 |
| Popis: | A computational model was developed for studying the flow field and particle deposition in a human upper airway system, including: nasal cavity, nasopharynx, oropharynx, larynx and trachea. A series of coronal CT scan images of a 24 year old woman was used to construct the 3D model. The Lagrangian and Eulerian approaches were used, respectively, to find the trajectories of micro-particles and concentration of nano-particles. The total and regional deposition fractions of micro/nanoparticles were evaluated and the major hot spots for the deposition of inhaled particles were found. |
| Databáze: | OpenAIRE |
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