Purine metabolism in pigs and humans and its implications for xenotransplantation
| Autor: | Zain Khalpey, Magdi H. Yacoub, R. T. Smolenski, H Dziewit, AC Yuen, Joanna Karbowska, Ewa M. Slominska, Zdzislaw Kochan, T. Borkowski, Marialuisa Lavitrano, M Zdunek |
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| Přispěvatelé: | Smolenski, R, Khalpey, Z, Yuen, A, Dziewit, H, Slominska, E, Borkowski, T, Zdunek, M, Kochan, Z, Karbowska, J, Lavitrano, M, Yacoub, M |
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Swine Transplantation Heterologous Uridine Triphosphate UTP Kidney Biochemistry Animals Genetically Modified ecto-5 '-nucleotidase chemistry.chemical_compound Adenosine Triphosphate Species Specificity xenotransplantation Internal medicine Genetics medicine Animals Humans Nucleotide Purine metabolism Inosine 5'-Nucleotidase Hypoxanthine Chromatography High Pressure Liquid Uridine triphosphate chemistry.chemical_classification Myocardium Uracil General Medicine nucleotide Uridine ATP Endocrinology chemistry Purines Molecular Medicine Uric acid purine metabolites medicine.drug |
| Zdroj: | Nucleosides, nucleotidesnucleic acids. 24(4) |
| ISSN: | 1525-7770 |
| Popis: | We compared concentrations of nucleotide substrates and activities of enzymes of nucleotide metabolism in pig and human blood, heart, and kidney. The most important difference was lower ecto-5'-nucleotidase (E5'N) activity in both pig hearts and kidney. Furthermore, higher hypoxanthine, inosine, adenine, and uracil, but lower uridine and uric acid concentrations were observed in pig blood as compared to human. A twofold increase in UTP concentration has been observed in pig hearts following 4 h perfusion with human blood. Purine metabolism is an important target for genetic and pharmacological manipulation during xenotransplantations. |
| Databáze: | OpenAIRE |
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