A self-delivery membrane system for enhanced anti-tumor therapy
| Autor: | Shi-Ying Li, Jun Feng, Lu Zhang, Li-Han Liu, Ming-Kang Zhang, Wen-Xiu Qiu, Chi Zhang, Fan Gao, Xian-Zheng Zhang, Bo-Ru Xie |
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| Rok vydání: | 2018 |
| Předmět: |
Integrin
Biophysics Bioengineering Peptide 02 engineering and technology 010402 general chemistry Models Biological 01 natural sciences Biomaterials Focal adhesion Cell membrane Drug Delivery Systems Immune system Cell Line Tumor medicine Animals Humans Self delivery chemistry.chemical_classification biology Cell Membrane 021001 nanoscience & nanotechnology 0104 chemical sciences Cell biology medicine.anatomical_structure Membrane chemistry Mechanics of Materials Cancer cell Ceramics and Composites biology.protein Peptides 0210 nano-technology |
| Zdroj: | Biomaterials. 161:81-94 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/j.biomaterials.2018.01.037 |
| Popis: | Nowadays, cell membrane targeting therapy has drawn much attention for its high anti-tumor effect by avoiding the cellular barriers. In this study, therapeutic agent conjugated chimeric peptide (Cp) was anchored in cracked cancer cell membranes (CCCM) to construct a self-delivery membrane system (M-Cp), which could relize precise cell membrane targeting therapy. It was found that compared with Cp, M-Cp could target to the cancer cell membrane with longer retention time, which is very crucial for in vivo applications. And the superior cell membrane targeting ability was attributed to the specific proteins (focal adhesion proteins, focal adhesion kinase, RHO family proteins, and integrin) on the CCCM surface. Importantly, the M-Cp could promote tumor-specific immune response, which further enhanced anti-tumor effect when combined with therapeutic agents in M-Cp. What's more, this self-delivery membrane system could be used as a template for cell membrane targeting therapy by changing the therapeutic agents as well as the CCCM, and this strategy would open a new window for various cell membrane targeting therapy. |
| Databáze: | OpenAIRE |
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