Immunopharmacological activities of 2-keto-3-deoxyoctonic acid-(alpha 2----6)-linked 4-O-phosphono-D-glucosamine derivatives carrying N- and 3-O-acyl substituents
| Autor: | Matsuura M, Homma Jy, K Inagaki, Terukazu Nagumo, Teisuke Furuya, Hasegawa A, Makoto Kiso, Hiroaki Takimoto, Yoshio Kumazawa |
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| Rok vydání: | 1989 |
| Předmět: |
Lipopolysaccharide
Stereochemistry Protein subunit Immunology Alpha (ethology) Biology Microbiology Sugar acids Lipid A chemistry.chemical_compound Mice Structure-Activity Relationship Adjuvants Immunologic Colony-Stimulating Factors Structure–activity relationship Animals cardiovascular diseases chemistry.chemical_classification Mice Inbred C3H Mice Inbred ICR Tumor Necrosis Factor-alpha nutritional and metabolic diseases Sugar Acids Biological activity carbohydrates (lipids) Mice Inbred C57BL Infectious Diseases chemistry Biochemistry Parasitology Tumor necrosis factor alpha lipids (amino acids peptides and proteins) Female Mitogens hormones hormone substitutes and hormone antagonists Research Article |
| Zdroj: | Infection and immunity. 57(6) |
| ISSN: | 0019-9567 |
| Popis: | The immunopharmacological activities of 2-keto-3-deoxyoctonic acid (KDO)-(alpha 2----6)-linked lipid A-subunit analogs, 4-O-phosphono-D-glucosamine derivatives carrying N- and 3-O-acyl substituents, were compared with those of the corresponding analogs without KDO, GLA-27, GLA-47, and GLA-60. Among the analogs tested, GLA-60, a 4-O-phosphono-D-glucosamine carrying N-3-hydroxytetradecanoyl and 3-O-3-tetradecanoyloxytetradecanoyl groups, exhibited the most intensive activities in terms of mitogenicity, adjuvanticity, and mediator (tumor necrosis factor and colony-stimulating factor) induction. Binding (alpha 2----6) of KDO to GLA-60 failed to enhance the activities. Similarly, the activities of GLA-27 and GLA-47 were also decreased by introduction of KDO to the O-6 of the analogs. This indicates that the strengths of the activities of the subunit analogs depend on the kinds of N- and 3-O-linked acyl substituents and not on the presence of the KDO linked to the O-6. |
| Databáze: | OpenAIRE |
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