Role of the PEBP4 protein in the development and metastasis of gastric cancer
| Autor: | Xuemin Zheng, Huijing Hou, Bin Liu, Zijian Wu, Ying Li |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Pathology medicine.medical_specialty Blotting Western Phosphatidylethanolamine Binding Protein Polymerase Chain Reaction Metastasis Phosphatidylinositol 3-Kinases 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms Cell Line Tumor medicine Humans Neoplasm Invasiveness Pharmaceutical sciences PEBP4 PI3K/AKT/mTOR pathway Aged Cell Proliferation Gene knockdown Cell growth Akt/PKB signaling pathway business.industry gastric cancer Cancer Middle Aged medicine.disease 030104 developmental biology cancer immigration Oncology Gene Knockdown Techniques 030220 oncology & carcinogenesis Cancer cell Cancer research Female business Proto-Oncogene Proteins c-akt cancer invasion Signal Transduction Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.15255 |
| Popis: | // Zijian Wu 1, * , Bin Liu 1, * , Xuemin Zheng 2 , Huijing Hou 1 , Ying Li 3 1 Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, China 2 Tianjin Institute of Pharmaceutical Research, China 3 Tianjin Neurological Institute, Tianjin Medical University General Hospital, China * These authors have contributed equally to this work Correspondence to: Zijian Wu, email: wzjian@tjcu.edu.cn Ying Li, email: liying11_@hotmail.com Keywords: gastric cancer, PEBP4, cancer immigration, cancer invasion Received: November 02, 2016 Accepted: December 28, 2016 Published: February 10, 2017 ABSTRACT Phosphatidylethanolamine-binding protein 4 (PEBP4) has previously been reported to be upregulated in various cancers. However, the physiological functions of PEBP4 in gastric cancer are still unknown. Aiming to clarify the properties and role of PEBP4 in the development and invasion of gastric cancer, we performed several biological assays and a knockdown assay. The expression level of PEBP4 was shown to be significantly upregulated in gastric cancer tissue samples, and knockdown of the expression of PEBP4 induced significant inhibitory effects on cell proliferation, migration and invasiveness. In addition, it was demonstrated that PEBP4 was associated with the development and invasion of gastric cancer cells through activation of the PI3K/Akt signaling pathway. Our findings supported the hypothesis that PEBP4 might be a novel potential drug target for the treatment of gastric cancer. |
| Databáze: | OpenAIRE |
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