| Autor: |
Joseph R. Testa, Siddharth Balachandran, Raja M. Flores, Suresh C. Jhanwar, Suresh Ramanathan, Eric A. Ross, Lauren A. Fox, Vladimir Khazak, Ting Zhang, Anna-Mariya Kukuyan, Craig W. Menges, Suraj Peri, Mitchell Cheung, Eleonora Sementino, Yinfei Tan |
| Rok vydání: |
2023 |
| DOI: |
10.1158/1078-0432.22473987 |
| Popis: |
Re-expression of RIPK3 expression triggers necroptosis in RIPK3-negative MM cell lines, and RIPK3 inhibition rescues the cell death caused by necroptosis. A, RIPK3-negative MM cell lines M12 and M22 were transduced with WPI lentivirus expressing RIPK3 WT or empty vector and treated with the apoptosis inhibitor zVAD and/or the RIPK3 inhibitor GSK'872 for 1-4 d. Results of immunoblot analysis (24 h) and clonogenic assay (4 d) are shown. B, Cell viability determined with hemocytometer and trypan blue dye exclusion test. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
