Effects of Antihypertensive Agents on Blood Pressure during Exercise
| Autor: | Satoshi Handa, Mikio Arita, Yoshio Wanaka, Toshikazu Hashizume, Ichiro Nishio, Setsuko Fujiwara, Chigusa Nakamura |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology Hemodynamics Blood Pressure Left ventricular hypertrophy Essential hypertension Internal medicine Heart rate Internal Medicine Humans Medicine Amlodipine Exercise physiology Exercise Antihypertensive Agents business.industry Middle Aged medicine.disease Blood pressure Echocardiography Hypertension Exercise Test Cardiology Aortic pressure Female Hypertrophy Left Ventricular Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Hypertension Research. 24:671-678 |
| ISSN: | 0916-9636 |
| Popis: | The relationship between blood pressure (BP) and cardiovascular morbidity has been appreciated for many years. Casual BP may not be representative of the pressure at other times. It is recognized that BP during exercise may be a more accurate predictor than casual BP. There is, however, little information about the effects of antihypertensive drugs on the BP during exercise. This study was designed to investigate the effects of various antihypertensive agents on BP during exercise. Sixty-four patients (age, 49+/-10 years) with untreated essential hypertension (WHO I, II) were studied during a supine ergometric exercise regimen. A graded exercise test was started at a workload of 50 W, and the load was increased by 25 W every 3 min. The hemodynamic responses to exercise were evaluated by changes in systolic and diastolic BP (SBP, DBP) and heart rate (HR). Plasma norepinephrine (NE) levels were measured at rest and during submaximal exercise, and before and after 4 weeks of treatment with metoprolol (METO), doxazosin (DOXA), trichlormethiazide (TCTZ), nifedipine (NIFE), amlodipine (AMLO) and temocapril (TEMO) between left ventricular mass index (LVMI) and BP values at rest, during exercise, and during the recovery period after exercise were assessed by multiple regression analysis. The stepwise selection (forward conditional) method showed that LVMI was significantly associated with SBP during submaximal exercise and during the recovery period. All antihypertensive treatments decreased SBP and DBP (p |
| Databáze: | OpenAIRE |
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