Leaf-surface guaianolides from Amphoricarpos neumaeyri showing protective effect on human lymphocytes DNA
| Autor: | Ljubodrag Vujisić, Boris Mandić, Slobodan Milosavljević, Milka Jadranin, Mirjana Cvetković, Iris Djordjevic, Miroslava Stanković |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
biology
010405 organic chemistry Chemistry Stereochemistry Amphoricarpos neumayeri Organic Chemistry Plant Science biology.organism_classification Sesquiterpene Amphoricarpos neumayeri Vis 01 natural sciences Biochemistry Skeleton (computer programming) Amphoricarpos 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry chemistry.chemical_compound in vitro protective effect on chromosome aberrations sesquiterpene lactones Composition (visual arts) DNA |
| Zdroj: | Natural Product Research |
| Popis: | Analysis of composition of CH2Cl2 surface extract of leaves of Amphoricarpos neumayeri Vis. revealed 16 sesquiterpene lactones with guaianolide skeleton, so called amphoricarpolides, typical for this genus. Four of them, 13–16, were new derivatives and their structures were elucidated by detailed analyses of IR, NMR and MS data. Amphoricarpolide (9), its 15-O-acetyl derivative (5), and two 9β-hydroxyamphoricarpolides, 3,15-di-O-acetyl- and 3-O-acetyl-15-O-isovaleroyl derivatives (3 and 6, respectively) were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The tested compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes. |
| Databáze: | OpenAIRE |
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