Symmetry OUT, Asymmetry IN
| Autor: | Leonor Saúde, Raquel Lourenço |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Physics and Astronomy (miscellaneous)
General Mathematics media_common.quotation_subject Biology Asymmetry 03 medical and health sciences left-right asymmetry 0302 clinical medicine biology.animal Computer Science (miscellaneous) Segmentation segmentation clock 030304 developmental biology media_common 0303 health sciences Segmentation Clock Bilateral synchronization lcsh:Mathematics Vertebrate lcsh:QA1-939 bilateral synchronization Body plan Chemistry (miscellaneous) Laterality Symmetry (geometry) Neuroscience 030217 neurology & neurosurgery organ laterality |
| Zdroj: | Symmetry, Vol 2, Iss 2, Pp 1033-1054 (2010) |
| ISSN: | 2073-8994 |
| Popis: | The formation of a perfect vertebrate body plan poses many questions that thrill developmental biologists. Special attention has been given to the symmetric segmental patterning that allows the formation of the vertebrae and skeletal muscles. These segmented structures derive from bilaterally symmetric units called somites, which are formed under the control of a segmentation clock. At the same time that these symmetric units are being formed, asymmetric signals are establishing laterality in nearby embryonic tissues, allowing the asymmetric placement of the internal organs. More recently, a “shield” that protects symmetric segmentation from the influence of laterality cues was uncovered. Here we review the mechanisms that control symmetric versus asymmetric development along the left-right axis among vertebrates. We also discuss the impact that these studies might have in the understanding of human congenital disorders characterized by congenital vertebral malformations and abnormal laterality phenotypes. |
| Databáze: | OpenAIRE |
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