Construction of 3,12-Diazatetracyclododecane-dienes through Unexpected Visible-Light-Induced Radical Cascade Cyclization

Autor: Qidi Zhong, Yinxin Wang, Hanyang Lan, Hao Zhu, Qiangwen Fan
Rok vydání: 2022
Předmět:
Zdroj: The Journal of organic chemistry. 87(16)
ISSN: 1520-6904
Popis: A novel visible-light-induced cascade radical cyclization reaction of 3-cyano-4-aryl-1,4-dihydropyridines for the construction of 3,12-diazatetracyclododecane-diene derivatives is reported for the first time. In the presence of 410 nm blue LED lamp as the light source and ethanol as the solvent, the reactions proceed smoothly to afford photocyclization products in good yields. The process is carried out through the breaking of original C═C double bonds and the formation of three new single bonds in one pot and proved to be able to tolerate different substituents.
Databáze: OpenAIRE