Antigen-specific responses and ANA production in B6.Sle1b mice: A role for SAP
| Autor: | Paula Jennings, Alice Y. Chan, Dorothy Yuan, Pamela L. Schwartzberg, Edward K. Wakeland |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
T-Lymphocytes
Immunology Antigen presentation Context (language use) Lymphocyte Activation Article Mice Antigen medicine Animals Lupus Erythematosus Systemic Immunology and Allergy Signaling Lymphocytic Activation Molecule Associated Protein Mice Knockout Antigen Presentation B-Lymphocytes Systemic lupus erythematosus biology Intracellular Signaling Peptides and Proteins Autoantibody medicine.disease Antigens T-Independent Molecular biology Killer Cells Natural Mice Inbred C57BL medicine.anatomical_structure Antibodies Antinuclear biology.protein Antibody Signal transduction Memory T cell Signal Transduction |
| Zdroj: | Journal of Autoimmunity. 31:345-353 |
| ISSN: | 0896-8411 |
| DOI: | 10.1016/j.jaut.2008.08.002 |
| Popis: | B6.Sle1b mice, which contain the Sle1b gene interval derived from lupus prone NZM2410 mice on a C57BL/6 background, present with gender-biased, highly penetrant anti-nuclear antibody (ANA) production. To obtain some insight into the possible induction mechanism of autoantibodies in these mice we compared antigen specific T dependent (TD) and T independent (TI-II) responses between B6.Sle1b and B6 mice before the development of high ANA titers. Our results show that B6.Sle1b mice mount enhanced responses to a TI-II antigen. Additionally, the memory T cell response generated by a TD antigen was also increased. This enhancement correlates with the greater ability of B cells from B6.Sle1b mice to present antigen to T cells. The SLAM Associated Protein (SAP) is critical for signaling of many of the molecules encoded by the SLAM/CD2 gene cluster, candidates for mediating the Sle1b phenotype; therefore, we also investigated the effect of sap deletion in these strains on the TD and TI-II responses as well as on ANA production. The results of these studies of responses to non-self antigens provide further insight for the mechanism by which responses to self-antigens might be initiated in the context of specific genetic alterations. |
| Databáze: | OpenAIRE |
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