Effect of131Iodine Therapy on the Course of Graves' Ophthalmopathy: A Quantitative Analysis of Extraocular Muscle Volumes Using Orbital Magnetic Resonance Imaging
| Autor: | M. Gliga, J.A. Foster, Manjula K. Gupta, L.R. Sheeler, N. McBride, M.R. Faiman, Charles Faiman, J. Perl, R. Beham, A.E. Mehta, R. Dattatreya |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Endocrinology Diabetes and Metabolism Graves' disease Levothyroxine Muscle hypertrophy Iodine Radioisotopes Graves' ophthalmopathy Endocrinology medicine Humans Prospective Studies Prospective cohort study Aged medicine.diagnostic_test business.industry Muscles Medial rectus muscle Magnetic resonance imaging Hypertrophy Middle Aged medicine.disease Magnetic Resonance Imaging Graves Disease medicine.anatomical_structure Female Nuclear medicine business Orbit medicine.drug Orbit (anatomy) |
| Zdroj: | Thyroid. 11:959-965 |
| ISSN: | 1557-9077 1050-7256 |
| DOI: | 10.1089/105072501753211037 |
| Popis: | There remains uncertainty as to the effect of radioactive iodine (131I) therapy on the associated ophthalmopathy (GO). Twenty newly diagnosed patients with Graves' hyperthyroidism treated with 131I (median dose, 15.5 mCi) were followed with ophthalmologic evaluations (OE) and magnetic resonance imaging (MRI) at baseline, 2, and 6 months, and with OE alone at 3 years. For MRI, the superior, inferior, and medial rectus muscle volumes and total muscle volumes (TMV) were measured. Replacement levothyroxine was initiated as low thyroxine (T4) levels were noted. At baseline, 10 patients (50%) showed evidence of mild GO by OE and/or MRI. There was a significant difference in TMV between the 20 patients with Graves' hyperthyroidism and 10 controls (mean +/- standard error [SE]; 2,652 +/- 118 vs. 2,046 +/- 96 mm3; P = 0.002) and between the 10 patients with and 10 without GO (3,006 +/- 96 vs. 2,298 +/- 61 mm3; P = 0.001). TMV correlated with the Hertel score (r = 0.56, P = 0.01). TMV showed no significant change at 2 or 6 months posttreatment. The inferior rectus volume increased slightly at 2 months posttreatment (P = 0.03) but remained stable at 6 months. Furthermore, no significant changes occurred in Hertel scores or in clinical assessments up to 3 years posttreatment and none showed worsening or new development of GO. In conclusion, our results show no significant risk for radioiodine-induced initiation or progression of mild GO. |
| Databáze: | OpenAIRE |
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