A Mouse Model of Furosemide-Induced Overactive Bladder
| Autor: | Eva Zuvich, Amy DiCamillo, Michael S. Saporito |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Urinary system media_common.quotation_subject Urinary Bladder 030232 urology & nephrology Urology Urination Urinary incontinence Urine Muscarinic Antagonists 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Furosemide medicine Animals Oxybutynin media_common business.industry Urinary Bladder Overactive General Medicine medicine.disease Disease Models Animal 030104 developmental biology Baclofen Urinary Incontinence Overactive bladder chemistry Treatments for overactive bladder medicine.symptom business medicine.drug |
| Zdroj: | Current Protocols in Pharmacology |
| ISSN: | 1934-8290 |
| Popis: | Detailed in this unit is a mouse model of overactive bladder and urinary incontinence based on diuretic stress-induced urination. The procedure involves the use of a unique, highly sensitive, and automated urine capturing method to measure urinary latency, frequency, and void volume. Although this method was first described and validated using an anti-muscarinic drug used for treating overactive bladder, subsequent work has shown that effective non-cholinergic agents can be detected. These findings indicate good predictive value for this model regarding the possible clinical utility of test agents as treatments for overactive bladder, regardless of their site of action. © 2016 by John Wiley & Sons, Inc. Keywords: urinary incontinence; micturition; muscarinic receptor; GABAB receptor; oxybutynin; baclofen |
| Databáze: | OpenAIRE |
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