18F-FDG PET/CT IN DIFFERENTIATED THYROID CARCINOMA
| Autor: | Katalin Gabora, Maria Iulia Larg, Doina Piciu, M Cheptea, Claudiu Pestean, Elena Barbus |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
PET-CT
medicine.diagnostic_test Endocrine and Autonomic Systems business.industry Endocrine Care Endocrinology Diabetes and Metabolism Thyroid 030209 endocrinology & metabolism External radiotherapy Thyroid carcinoma 03 medical and health sciences 0302 clinical medicine Endocrinology medicine.anatomical_structure Elevated thyroglobulin Positron emission tomography 030220 oncology & carcinogenesis Medicine In patient Fdg pet ct business Nuclear medicine |
| Popis: | Aim Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) become an important tool in oncology by combining the metabolic information from 18F-FDG PET with the morphological information of CT. The main objective of this study was to assess the diagnostic value of PET/CT in patients with differentiated thyroid carcinoma (DTC). Material and methods We analyzed 173 PET/CT scans of patients with DTC presenting elevated thyroglobulin (Tg) levels, negative Tg-antibodies levels, negative Iodine-131 whole-body scanning (I-131 WBS) and without any signs of clinical or other imaging technique for tumor recurrence/metastases. Results PET/CT scans were positive in 38% of cases (65/173). The sensitivity, specificity, positive predictive values and the accuracy of PET/CT imaging were 88.09%, 98.6%, 93.1% respectively 96.53%. After the PET/CT scan 29 patients underwent surgery, 24 of them continued radio-iodine therapy, 5 patients initiated tyrosine kinase inhibitors treatment and external radiotherapy. Conclusion 18F-FDG PET/CT is a valuable imaging technique which has the capability of identifying those cases of thyroid recurrence/metastases with elevated Tg levels and negative I-131 WBS. The treatment strategy was changed in 89.2% cases of positive PET/CT scans which shows us that 18F-FDG PET/CT imaging should be integrated into the follow-up programs for DTC patients. |
| Databáze: | OpenAIRE |
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