Relationship Between Leukocyte Telomere Length and Personality Traits in Healthy Subjects
| Autor: | Akihito Suzuki, Yoshihiko Matsumoto, Ryoichi Sadahiro, Koichi Otani, Kaoru Goto, Naoshi Shibuya, Masanori Enokido, Mitsuhiro Kamata |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Character Personality Inventory media_common.quotation_subject Disease 050105 experimental psychology Revised NEO Personality Inventory Developmental psychology Extraversion Psychological 03 medical and health sciences 0302 clinical medicine Asian People Japan Reward Leukocytes Humans Personality 0501 psychology and cognitive sciences Cooperative Behavior Mortality Big Five personality traits Temperament Gene media_common Neuroticism Genetics 05 social sciences Telomere Anxiety Disorders Healthy Volunteers Self Efficacy Psychiatry and Mental health Female Temperament and Character Inventory Psychology 030217 neurology & neurosurgery |
| Zdroj: | European Psychiatry. 30:291-295 |
| ISSN: | 1778-3585 0924-9338 |
| DOI: | 10.1016/j.eurpsy.2014.03.003 |
| Popis: | Background:It has been shown that certain personality traits are related to mortality and disease morbidity, but the biological mechanism linking them remains unclear. Telomeres are tandem repeat DNA sequences located at the ends of chromosomes, and shorter telomere length is a predictor of mortality and late-life disease morbidity. Thus, it is possible that personality traits influence telomere length. In the present study, we examined the relationship of leukocyte telomere length with personality traits in healthy subjects.Subjects and methods:The subjects were 209 unrelated healthy Japanese who were recruited from medical students at 4th–5th grade. Assessment of personality traits was performed by the Revised NEO Personality Inventory (NEO-PI-R) and the Temperament and Character Inventory (TCI). Leukocyte relative telomere length was determined by a quantitative real-time PCR method for a ratio of telomere/single copy gene.Results:In the stepwise multiple regression analysis, shorter telomere length was related to lower scores of neuroticism (P < 0.01) and conscientiousness (P < 0.05) of the NEO-PI-R, and lower scores of harm avoidance (P < 0.05) and reward dependence (P < 0.05) of the TCI.Conclusions:The present study suggests that leukocyte telomere length is associated with some personality traits, and this association may be implicated in the relationship between personality traits and mortality. |
| Databáze: | OpenAIRE |
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