Patterned frequency-modulated oral stimulation in preterm infants: A multicenter randomized controlled trial

Autor: Sunshine Pooley, Daniel Vail, Tania Cornejo, Mary Wearden, Dongli Song, Suhas Nafday, Diane V Thompson, Jonathan Nedrelow, Priya Jegatheesan, Balaji Govindaswami, Sheri L. Nemerofsky, Zahava Cohen, Kaashif A. Ahmad
Rok vydání: 2019
Předmět:
Male
Physiology
Maternal Health
Health Care Providers
Pulsatile flow
Nurses
Stimulation
Pediatrics
law.invention
Families
0302 clinical medicine
Randomized controlled trial
law
Medicine and Health Sciences
Medicine
Medical Personnel
030212 general & internal medicine
Children
Multidisciplinary
Ingestion
Pacifiers
Professions
Breast Feeding
Treatment Outcome
Infant
Extremely Premature
Anesthesia
Gestation
Female
Infants
Research Article
Drug Research and Development
Science
Research and Analysis Methods
03 medical and health sciences
Enteral Nutrition
Swallowing
030225 pediatrics
Humans
Clinical Trials
Respiratory Physiology
Pharmacology
Proportional hazards model
business.industry
Infant
Newborn
Biology and Life Sciences
Feeding Behavior
Randomized Controlled Trials
Health Care
Age Groups
People and Places
Pacifier
Women's Health
Population Groupings
Neonatology
Clinical Medicine
Health Statistics
Morbidity
Physiological Processes
business
Breast feeding
Zdroj: PLoS ONE
PLoS ONE, Vol 14, Iss 2, p e0212675 (2019)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0212675
Popis: Objective To evaluate the effect of patterned, frequency-modulated oro-somatosensory stimulation on time to full oral feeds in preterm infants born 26–30 weeks gestation. Study design This is a multicenter randomized controlled trial. The experimental group (n = 109) received patterned, frequency-modulated oral stimulation via the NTrainer system through a pulsatile pacifier and the control group (n = 101) received a non-pulsatile pacifier. Intent-to-treat analysis (n = 210) was performed to compare the experimental and control groups and the outcomes were analyzed using generalized estimating equations. Time-to-event analyses for time to reach full oral feeds and length of hospital stay were conducted using Cox proportional hazards models. Results The experimental group had reduction in time to full oral feeds compared to the control group (-4.1 days, HR 1.37 (1.03, 1.82) p = 0.03). In the 29–30 weeks subgroup, infants in the experimental group had a significant reduction in time to discharge (-10 days, HR 1.87 (1.23, 2.84) p < 0.01). This difference was not observed in the 26–28 weeks subgroup. There was no difference in growth, mortality or morbidities between the two groups. Conclusions Patterned, frequency-modulated oro-somatosensory stimulation improves feeding development in premature infants and reduces their length of hospitalization. Trial registration ClinicalTrials.gov NCT01158391
Databáze: OpenAIRE
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