| Autor: |
Do-Hyun Nam, Jeongwu Lee, Jeremy N. Rich, Jung-Il Lee, Doo-Sik Kong, Ho Jun Seol, Hyunggee Kim, Paul H. Song, Kwang Ho Cheong, Justin D. Lathia, Youn-Jung Kang, Bong Gu Kang, Yonghyun Kim, Kang Ho Kim, Eunhee Kim, Juyoun Jin, Kyeung Min Joo |
| Rok vydání: |
2023 |
| DOI: |
10.1158/0008-5472.22393664 |
| Popis: |
PDF file - 6.4MB, Figure S1: High MET mRNA expression in GBM specimens portends poor patient survival. Figure S2: Dual immunofluorescence of MET and GSC enrichment markers (CD133 and CD15) on the frozen sections of GBM specimens. Figure S3: HGF/MET signaling in GBMs. Figure S4: METhigh cells generated xenograft tumors consisting of both METhigh and METlow/- cells. Figure S5: Immunohistochemical analysis of HGF protein in orthotopic xenograft tumors derived of from GBM 578 (A and C) and 464 (B and D). Figure S6: Effects of MET blockade on cell survival and clonogenicity of GSCs. Figure S7: In vitro migration and invasion assays using GSCs with MET targeting. Figure S8: Immunohistochemical analysis using human nuclei-specific antibody on the sections of GBM xenografts. Figure S9: Limiting dilution sphere forming assay to determine the clonogenic potentials of 822 GSCs after treatments of radiation and SU11274 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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