Threshold effect for lipoprotein(a) in aortic stenosis
| Autor: | Evangelos Tzolos, Marc R. Dweck |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Hyperlipoproteinemias medicine.medical_treatment 030204 cardiovascular system & hematology Time-to-Treatment 03 medical and health sciences 0302 clinical medicine Ezetimibe Internal medicine medicine Secondary Prevention Humans 030212 general & internal medicine Lipid Regulating Agents Percutaneous aortic valve replacement biology business.industry Patient Selection valvular heart disease Calcinosis Lipoprotein(a) Aortic Valve Stenosis medicine.disease Clinical trial Stenosis Heart Disease Risk Factors Aortic valve stenosis Aortic Valve biology.protein Cardiology Disease Progression Cardiology and Cardiovascular Medicine business Lipoprotein medicine.drug |
| Zdroj: | Heart (British Cardiac Society). 107(17) |
| ISSN: | 1468-201X |
| Popis: | Calcific aortic stenosis (AS) is the most common form of valvular heart disease in the Western world, and its healthcare burden is expected to double over the next 50 years.1 Currently, no medical therapy has demonstrated an ability to slow or halt progression of this common condition. While surgical or percutaneous aortic valve replacement is the only available treatment, important questions still remain with respect to the optimal timing of intervention, associated procedural risks and long-term durability. The quest to develop novel treatments to prevent or slow down AS, potentially removing the need for surgical intervention altogether, has not been successful up to now. Atherogenic apolipoprotein B-containing lipoproteins, like low-density lipoprotein (LDL) and lipoprotein(a) (Lp(a)), have been clearly implicated in the pathophysiology of AS, in particular in the initiation phase of the disease and with incident AS. However, multiple randomised clinical trials Simvastatin and Ezetimibe in Aortic Stenosis (SEAS), Scottish Aortic Stenosis and Lipid Lowering Trial, Impact in Regression (SALTIRE) and Aortic Stenosis Progression Observation: Measuring Effects of … |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|