Prospective evaluation of cell kinetics in head and neck squamous carcinoma: the relationship to tumour factors and survival
| Autor: | Andrew S. Jones, P. M. Stell, L. D. Cooke, TG Cooke, G. Forster |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1994 |
| Předmět: |
Oncology
Adult Male Cancer Research Pathology medicine.medical_specialty Mitotic index Cell Count Biology S Phase Labelling Internal medicine medicine Carcinoma Mitotic Index Doubling time Humans Prospective Studies Survival rate Survival analysis Aged Neoplasm Staging Aged 80 and over Analysis of Variance Chi-Square Distribution DNA Neoplasm Middle Aged medicine.disease Aneuploidy Flow Cytometry Prognosis Survival Analysis Squamous carcinoma Survival Rate Bromodeoxyuridine Head and Neck Neoplasms Carcinoma Squamous Cell T-stage Female Cell Division Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Tumour growth rates were measured in 105 patients using in vivo incorporation of bromodeoxyuridine (BrdU) and investigated for any relationship to tumour factors or survival. The median labelling index (LI) was 8.7%, the duration of S-phase (Ts) was 14 h and the potential doubling time (Tpot) was 5.9 days. The labelling index in aneuploid tumours was significantly higher than that in diploid tumours. However the total labelling index (TLI) did not differ significantly between aneuploid and diploid tumours, and so it would seem likely that the difference in LI is due to the dilutional effect of benign tissue upon the calculation of LI in diploid tumours. The total labelling index, duration of S-phase and potential doubling time were not related to the tumour factors examined (site, T stage, N stage, stage grouping). Interim survival analysis was carried out and there was no difference in survival between those patients with high values for TLI, Ts, and Tpot and those with low values. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|