Dna2 offers support for stalled forks

Autor: Marco Foiani, Mong Sing Lai
Rok vydání: 2012
Předmět:
Zdroj: Cell. 149(6)
ISSN: 1097-4172
Popis: The ATR and ATM checkpoint kinases preserve the integrity of replicating chromosomes by preventing the reversal of stalled and terminal replication forks. Hu et al. now show that the ATR pathway targets the Dna2 nuclease to process stalled forks and counteract fork reversal.
Databáze: OpenAIRE