Atrial Natriuretic Peptide and the Natriuresis Due to Acute β-Blockade in Conscious Hypertensive Rats
| Autor: | May Sjölander, Knut Pettersson, John Anderson, Stephen R. Bloom |
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| Rok vydání: | 1987 |
| Předmět: |
Male
medicine.medical_specialty Sodium Natriuresis chemistry.chemical_element Basal (phylogenetics) Atrial natriuretic peptide Rats Inbred SHR Internal medicine Receptors Adrenergic beta Internal Medicine medicine Animals Metoprolol business.industry Rats Blockade Blood pressure Endocrinology Mechanism of action chemistry Hypertension medicine.symptom business Atrial Natriuretic Factor medicine.drug |
| Zdroj: | Clinical and Experimental Hypertension. Part A: Theory and Practice. 9:95-107 |
| ISSN: | 0730-0077 |
| DOI: | 10.3109/10641968709160032 |
| Popis: | Acute β-adrenoceptor blockade in rats is known to produce a natriuresis of hitherto uncertain cause. To investigate this phenomenon plasma atrial natriuretic peptide (ANP) concentrations were measured in groups of conscious metoprolol-treated and control rats. in the active treatment group the blood pressure decreased slowly, as expected, settling at a lower level after 2 hours, and the mean sodium excretion doubled 1 hour after metoprolol administration. This natriuretic effect was maximal after 40-60 minutes and thereafter slowly declined towards basal values. The period of enhanced sodium excretion was associated with a significant rise (68 %) of the mean ANP plasma concentration. It is suggesteU that this increase in plasma ANP concentration can mediate the acute natriuretic effect of β-adrenoceptor blockade. |
| Databáze: | OpenAIRE |
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