Genome-Wide Association Study Confirms SNPs inSNCAand theMAPTRegion as Common Risk Factors for Parkinson Disease
| Autor: | Liyong Wang, William K. Scott, Burton L. Scott, Eden R. Martin, Margaret A. Pericak-Vance, Fatta B. Nahab, Stephan Züchner, Ioanna Konidari, Eric Powell, Cherylyn Almonte, Jonathan L. Haines, Todd L. Edwards, Gary W. Beecham, Amber Burt, Carlos Singer, Gaofeng Wang, Jeffery M. Vance, Jeffrey M. Stajich |
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| Rok vydání: | 2010 |
| Předmět: |
Genetics
Haplotype Parkinson Disease tau Proteins Single-nucleotide polymorphism Genome-wide association study Odds ratio Biology Polymorphism Single Nucleotide Article Attributable risk alpha-Synuclein Genetic predisposition Humans Allele Genetics (clinical) Genome-Wide Association Study Genetic association |
| Zdroj: | Annals of Human Genetics. 74:97-109 |
| ISSN: | 1469-1809 0003-4800 |
| Popis: | Parkinson disease (PD) is a chronic neurodegenerative disorder with a cumulative prevalence of greater than one per thousand. To date three independent genome-wide association studies (GWAS) have investigated the genetic susceptibility to PD. These studies implicated several genes as PD risk loci with strong, but not genome-wide significant, associations. In this study, we combined data from two previously published GWAS of Caucasian subjects with our GWAS of 604 cases and 619 controls for a joint analysis with a combined sample size of 1752 cases and 1745 controls. SNPs in SNCA (rs2736990, p-value = 6.7 x 10(-8); genome-wide adjusted p = 0.0109, odds ratio (OR) = 1.29 [95% CI: 1.17-1.42] G vs. A allele, population attributable risk percent (PAR%) = 12%) and the MAPT region (rs11012, p-value = 5.6 x 10(-8); genome-wide adjusted p = 0.0079, OR = 0.70 [95% CI: 0.62-0.79] T vs. C allele, PAR%= 8%) were genome-wide significant. No other SNPs were genome-wide significant in this analysis. This study confirms that SNCA and the MAPT region are major genes whose common variants are influencing risk of PD. |
| Databáze: | OpenAIRE |
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