Paraneoplastic Focal Outer Retinitis and Optic Neuropathy in a Patient with Small Cell Lung Carcinoma and Anti-CRMP5, Anti-HU and Anti-Amphiphysin Antibodies
| Autor: | Alex Fonollosa, Joseba Artaraz, Inazio Lacambra, Clara Martínez-Rubio, Lena Giralt |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty Ataxia genetic structures medicine.medical_treatment Retinitis Case Report Malignancy 01 natural sciences Optic neuropathy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Atrophy lcsh:Ophthalmology medicine 0101 mathematics Optic disc oedema business.industry 010102 general mathematics Retinal medicine.disease Collapsin response mediator protein 5 eye diseases Radiation therapy Ophthalmology chemistry lcsh:RE1-994 030221 ophthalmology & optometry Paraneoplastic syndrome Small Cell Lung Carcinoma sense organs medicine.symptom business |
| Zdroj: | Case Reports in Ophthalmology Case Reports in Ophthalmology, Vol 11, Iss 3, Pp 507-515 (2020) |
| ISSN: | 1663-2699 |
| Popis: | Our aim is to describe clinical and optical coherence tomographic features of acute paraneoplastic focal outer retinitis associated with optic neuropathy in a patient diagnosed with small cell lung carcinoma. Bilateral focal outer retinitis, bilateral optic disc oedema and vitritis were identified in a patient with progressive bilateral visual loss and ataxia. Spectral domain optical coherence tomography (SD-OCT) revealed various extents of granular hyperreflectivity and atrophy of the macular outer retinal layers. Serum and cerebrospinal fluid positivity for anti-CRMP5, anti-HU and anti-amphiphysin antibodies intensified the search for an underlying malignancy, and a small cell lung carcinoma (SCLC) was finally diagnosed. Local and oral steroids along with systemic chemotherapy and radiotherapy achieved cancer remission and partial recovery from the ophthalmic manifestations. Focal outer retinitis associated with optic disc oedema and antibody positivity facilitated the diagnosis of SCLC in a localized stage. SD-OCT allowed the characterization of this entity, expanding the spectrum of paraneoplastic ophthalmological syndromes. |
| Databáze: | OpenAIRE |
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