Multipotent Progenitor Cells in Gingival Connective Tissue
| Autor: | Jean-Jacques Lataillade, Adrien Naveau, Ludovic Couty, Bernard Coulomb, Benjamin Fournier, Antoine Lafont, Murielle Gourven, François Côme Ferré, Bruno Gogly |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Cellular differentiation Blotting Western Population Gingiva Biomedical Engineering Connective tissue Bioengineering Biology Biochemistry Biomaterials Cell therapy Young Adult Chondrocytes Adipocytes medicine Humans Progenitor cell education Cells Cultured Aged education.field_of_study Osteoblasts Multipotent Stem Cells Mesenchymal stem cell Cell Differentiation Fibroblasts Middle Aged Flow Cytometry Immunohistochemistry Cell biology medicine.anatomical_structure Multipotent Stem Cell Immunology Calcium Female Wound healing |
| Zdroj: | Tissue Engineering Part A. 16:2891-2899 |
| ISSN: | 1937-335X 1937-3341 |
| DOI: | 10.1089/ten.tea.2009.0796 |
| Popis: | The gum has an exceptional capacity for healing. To examine the basis for this property and explore the potential of conferring it to organs with inferior healing capacity, we sought the presence of progenitor cells in gingival connective tissue. Colony-forming units of fibroblast-enriched cells from gingival fibroblast cultures were assessed for expression of membrane markers of mesenchymal stem cells; capacity to differentiate into osteoblasts, chondroblasts, and adipocytes; and engraftment efficiency after in vivo transfer. On the basis of their ability to differentiate into several lineages, proliferate from single cells, induce calcium deposits, and secrete collagen in vivo after transfer on hydroxyapatite carriers, we suggest that this population represents gingival multipotent progenitor cells. The discovery of progenitor cells in gingival connective tissue may help improve our understanding of how the wounded gum is capable of almost perfect healing and opens the prospect of cellular therapy for wound healing using readily available cells at limited risk to the patient. |
| Databáze: | OpenAIRE |
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