Kinetics of 2,4,6-trichlorophenol in different organs of the rat
| Autor: | K. Pekari, A. Aitio, C. Boudène |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Chromatography
Gas Health Toxicology and Mutagenesis Kinetics Pharmacology toxicology Glucuronates Toxicology Body weight chemistry.chemical_compound medicine Animals Tissue Distribution Tissue distribution Chlorophenol Kidney Chromatography Rats Inbred Strains General Medicine Organ Size Rats medicine.anatomical_structure chemistry Organ Specificity 2 4 6-Trichlorophenol Female Chlorophenols |
| Zdroj: | Archives of toxicology. 59(1) |
| ISSN: | 0340-5761 |
| Popis: | The concentration of 2,4,6-trichlorophenol was measured in the blood and various other tissues of the rat after IP administration of the compound at 25 mg per kg body weight. The highest concentration, 329 +/- 117 nmol X g-1, was found in the kidney. Half-times were between 1.4 and 1.8 h in the blood, brain, fat, kidney, liver and muscle. The extent of conjugation of 2,4,6-trichlorophenol was also investigated by measuring total and free chlorophenol in the blood. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink