Efficacy of intravenous immunoglobulin preparations against viral and bacterial infections in mouse protection tests
| Autor: | H. Dichtelmüller, W. Stephan |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Microbiology (medical)
Salmonella Immunoglobulin E medicine.disease_cause Virus Microbiology Mice Orthomyxoviridae Infections Neutralization Tests medicine Animals Antibacterial agent Salmonella Infections Animal Tetanus biology Toxin Biological activity General Medicine medicine.disease Virology Infectious Diseases Immunoglobulin G Injections Intravenous biology.protein Female Antibody |
| Zdroj: | Infection. 11:227-231 |
| ISSN: | 1439-0973 0300-8126 |
| DOI: | 10.1007/bf01641203 |
| Popis: | Our investigation indicates that pretreatment of human immunoglobulin for the elimination of the anticomplementary activity is associated with a loss of activity, the extent of which depends on the type of treatment applied. Laboratory preparations of human IgG were tested in a mouse protection assay using influenza A2-Taiwan virus, tetanus toxin and Salmonella typhimurium as the challenge. There was a 7-28% reduction in efficacy in an intravenous 7S preparation in comparison with an untreated 7S IgG. F(ab')2 fragments showed a 24-65% and Fab fragments an 80-100% reduction in efficacy. Two commercial human 7S products showed approximately 90% efficacy in the Salmonella assay; a commercial, pepsin-treated preparation showed 65-74% efficacy when compared with untreated 7S IgG. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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