Enteric Dysbiosis Associated with a Mouse Model of Alcoholic Liver Disease
| Autor: | Peter Stärkel, Manolito Torralba, Johannes Brandl, David A. Brenner, Hide Tsukamoto, Derrick E. Fouts, Bernd Schnabl, Arthur W. Yan, Eckart Schott, Karen E. Nelson |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Alcoholic liver disease
Liquid diet Alcoholic hepatitis Pancreatitis-Associated Proteins Biology Article Microbiology Mice RNA Ribosomal 16S Intestine Small medicine Animals Microbiome Liver Diseases Alcoholic Hepatology Fatty liver Proteins medicine.disease Small intestine Intestines Mice Inbred C57BL Disease Models Animal medicine.anatomical_structure Bacterial Translocation Dysbiosis Fatty Liver Alcoholic |
| Popis: | The translocation of bacteria and bacterial products into the circulation contributes to alcoholic liver disease. Intestinal bacterial overgrowth is common in patients with alcoholic liver disease. The aims of our study were to investigate bacterial translocation, changes in the enteric microbiome, and its regulation by mucosal antimicrobial proteins in alcoholic liver disease. We used a mouse model of continuous intragastric feeding of alcohol or an isocaloric diet. Bacterial translocation occurred prior to changes observed in the microbiome. Quantitative changes in the intestinal microflora of these animals were assessed first using conventional culture techniques in the small and large intestine. Although we found no difference after 1 day or 1 week, intestinal bacterial overgrowth was observed in the gastrointestinal tract of mice fed alcohol for 3 weeks compared with control mice fed an isocaloric liquid diet. Because |
| Databáze: | OpenAIRE |
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