Differential effects of dexamethasone, ondansetron and a tachykinin NK1 receptor antagonist (GR205171) on cisplatin-induced changes in behaviour, food intake, pica and gastric function in rats
| Autor: | Nasser M. Malik, Paul L.R. Andrews, Gareth J. Sanger, Yong-Ling Liu, Nicholas Cole |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Tetrazoles Antineoplastic Agents Motor Activity Dexamethasone Ondansetron Eating Neurokinin-1 Receptor Antagonists Piperidines Internal medicine medicine Antiemetic Animals Serotonin 5-HT3 Receptor Antagonists Rats Wistar Pharmacology business.industry Stomach Nausea Receptor antagonist Rats Endocrinology medicine.anatomical_structure Gastric Emptying Anorectic Pica Corticosteroid Antiemetics NK1 receptor antagonist Serotonin Antagonists Cisplatin business medicine.drug |
| Zdroj: | European journal of pharmacology. 555(2-3) |
| ISSN: | 0014-2999 |
| Popis: | This study aimed to dissect the mechanisms involved in malaise induced by the anti-cancer drug cisplatin by attempting to uncouple its effects on locomotor activity, arguably at least partly indicative of fatigue, from those effects indicative of emesis (pica, gastric stasis, reduced food intake) using pharmacological agents in the rat. Over 2 days cisplatin (6 mg/kg i.p.) reduced food intake, stimulated kaolin consumption, increased the wet weight of gastric contents and reduced locomotor activity. In animals treated with cisplatin: the 5-HT3 receptor antagonist ondansetron (1 mg/kg s.c. bd.) had no effect on either activity or weight of gastric contents but did increase food intake on day 1 (P |
| Databáze: | OpenAIRE |
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