Sp-5,6-Dichloro-1-β-D-Ribofuranosylbenzimidazole-3′,5′-Cyclic Monophosphorothioate is a Potent Stimulus for Insulin Release
| Autor: | Laychock Sg |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment 8-Bromo Cyclic Adenosine Monophosphate Stimulus (physiology) Biology Glucagon Rats Sprague-Dawley Endocrinology Internal medicine Insulin Secretion medicine Animals Insulin Secretion Cyclic GMP Pancreatic hormone Pancreatic islets General Medicine Thionucleotides In vitro Rats medicine.anatomical_structure Dichlororibofuranosylbenzimidazole |
| Zdroj: | Endocrine Research. 19:113-122 |
| ISSN: | 1532-4206 0743-5800 |
| DOI: | 10.3109/07435809309033018 |
| Popis: | The Sp-isomer of 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-cyclic monophosphorothioate (Sp-5,6-DCl-cBIMPS) at micromolar concentrations was a more potent stimulus for insulin release than 8-bromo-cyclic (c) AMP in isolated pancreatic islets of the rat. Sp-5,6-DCl-cBIMPS increased basal secretion, and potentiated glucose-stimulated insulin release to levels similar to those evoked by glucagon. A ten-fold higher concentration of 8-bromo-cAMP was required to mimic the potentiating effects of Sp-5,6-DCl-cBIMPS. Neither 8-para-chlorophenylthio-cGMP, 8-bromo-cGMP, nor dibutyryl-cGMP affected insulin release. Thus, Sp-5,6-DCl-cBIMPS is a potent and specific stimulus for cAMP-mediated insulin release. |
| Databáze: | OpenAIRE |
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