Monitoring of intense neuromuscular blockade in a pig model
| Autor: | Anders Meller Donatsky, Karsten Pharao Hammelev, Jacob Rosenberg, Bente Rona Jensen, Matias Vested Madsen, Mona Ring Gätke |
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| Rok vydání: | 2013 |
| Předmět: |
Swine
Health Informatics Stimulation Electromyography Critical Care and Intensive Care Medicine Sensitivity and Specificity Sugammadex medicine Animals Rocuronium Abdominal Muscles Neuromuscular Blockade medicine.diagnostic_test business.industry Reproducibility of Results Neuromuscular monitoring Diaphragm (structural system) Anesthesiology and Pain Medicine Treatment Outcome Neuromuscular Agents Anesthesia Kinetocardiography Female Neuromuscular Monitoring business Abdominal surgery medicine.drug |
| Zdroj: | Journal of clinical monitoring and computing. 28(4) |
| ISSN: | 1573-2614 |
| Popis: | Intense neuromuscular blockade (NMB) measured by post tetanic count (PTC) was monitored, reversed and verified in this pig model. In a cross-over assessor blinded design six pigs were randomized to either no NMB followed by intense NMB, or intense NMB followed by no NMB. Neuromuscular measurements were performed with acceleromyography [train-of-four (TOF) Watch SX]. In all pigs, the response to TOF nerve stimulation was stable and intense NMB (PTC 0–1) was established with rocuronium 3 mg/kg. For reversal, the pigs received sugammadex 20–35 mg/kg and returned to TOF-ratio above 0.90 within 2.15 min after injection. We established a pig model for monitoring intense NMB with surface stimulation electrodes and acceleromyography. We verified total relaxation of the diaphragm and the abdominal muscles at the PTC 0–1 by suction test and with surface electromyography. This pig model is suitable for studies with experimental abdominal surgery with monitoring of intense NMB, and where relaxation of the diaphragm and the abdominal muscles are required. |
| Databáze: | OpenAIRE |
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