Quercetin lowers plasma triglycerides accompanied by white adipose tissue browning in diet-induced obese mice

Autor: Mariëtte R. Boon, Andrea D. van Dam, Patrick C.N. Rensen, Riekelt H. Houtkooper, Ntsiki M. Held, Isabel M. Mol, Eline N. Kuipers
Přispěvatelé: AGEM - Endocrinology, metabolism and nutrition, Graduate School, AGEM - Inborn errors of metabolism, Laboratory Genetic Metabolic Diseases, APH - Aging & Later Life, ARD - Amsterdam Reproduction and Development
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
obesity
Flavonoid
White adipose tissue
030204 cardiovascular system & hematology
Antioxidants
Intestinal absorption
quercetin
lcsh:Chemistry
Mice
chemistry.chemical_compound
0302 clinical medicine
Adipose Tissue
Brown
Brown adipose tissue
heterocyclic compounds
triglycerides
lcsh:QH301-705.5
Uncoupling Protein 1
Spectroscopy
chemistry.chemical_classification
Chemistry
Fatty Acids
General Medicine
Thermogenin
Computer Science Applications
medicine.anatomical_structure
Quercetin
medicine.medical_specialty
Adipose Tissue
White
Diet
High-Fat
Article
Catalysis
Inorganic Chemistry
03 medical and health sciences
white adipose tissue
Internal medicine
medicine
Animals
Physical and Theoretical Chemistry
Molecular Biology
browning
Organic Chemistry
Fatty acid
brown adipose tissue
Mice
Inbred C57BL
030104 developmental biology
Endocrinology
Intestinal Absorption
lcsh:Biology (General)
lcsh:QD1-999
Diet-induced obese
Zdroj: International journal of molecular sciences, 19(6):1786. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 19, Iss 6, p 1786 (2018)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 19(6)
Volume 19
Issue 6
ISSN: 1661-6596
Popis: Obesity and dyslipidemia are major risk factors for the development of cardiovascular diseases (CVD). Quercetin, a natural flavonoid, lowers plasma triglycerides (TG) in human intervention studies, and its intake is associated with lower CVD risk. The aim of this study was to elucidate the mechanism by which quercetin lowers plasma TG levels in diet-induced obesity. C57Bl/6J mice received a high-fat diet (45% of calories derived from fat) with or without quercetin (0.1% w/w) for 12 weeks. Quercetin decreased plasma TG levels from nine weeks onwards (&minus
19%, p <
0.05), without affecting food intake, body composition, or energy expenditure. Mechanistically, quercetin did not reduce intestinal fatty acid (FA) absorption. Rather, quercetin induced a slight reduction in liver Apob expression (&minus
13%, p <
0.05), which suggests decreased very-low density lipoprotein-TG production. Interestingly, quercetin also markedly increased the uptake of [3H]oleate, which was derived from glycerol tri[3H]oleate-labeled lipoprotein-like particles by subcutaneous white adipose tissue (sWAT, +60%, p <
0.05). Furthermore, quercetin also markedly increased mRNA expression of Ucp1 (+229%, p <
0.05) and Elovl3 (+138%, p <
0.05), specifically in sWAT. Accordingly, only quercetin-treated animals showed uncoupling protein-1 protein-positive cells in sWAT, which is fully compatible with increased browning. Taken together, the TG-lowering effect of quercetin may, at least in part, be due to increased TG-derived FA uptake by sWAT as a consequence of browning.
Databáze: OpenAIRE
Externí odkaz: