Objective assessment of impulse control disorder in patients with Parkinson’s disease using a low-cost LEGO-like EEG headset: a feasibility study
| Autor: | Hsing-Yi Liang, Wei-Che Lin, Yuan-Pin Lin, Cheng-Hsien Lu, Yueh-Sheng Chen, Yung-Yee Chang, Yih-Ru Wu |
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| Rok vydání: | 2021 |
| Předmět: |
Event-related potential
medicine.medical_specialty Neurology Parkinson's disease Impulse control disorder Brain activity and meditation Headset Neurosciences. Biological psychiatry. Neuropsychiatry Health Informatics Audiology Electroencephalography 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Humans Medicine 0501 psychology and cognitive sciences Evoked Potentials medicine.diagnostic_test business.industry Research 05 social sciences Rehabilitation Motor control Parkinson Disease Impulse control disorders medicine.disease Disruptive Impulse Control and Conduct Disorders Electroencephalogram Parkinson’s disease Feasibility Studies LEGO-like headset business 030217 neurology & neurosurgery RC321-571 |
| Zdroj: | Journal of NeuroEngineering and Rehabilitation, Vol 18, Iss 1, Pp 1-12 (2021) Journal of NeuroEngineering and Rehabilitation |
| ISSN: | 1743-0003 |
| DOI: | 10.1186/s12984-021-00897-1 |
| Popis: | Background Patients with Parkinson’s disease (PD) can develop impulse control disorders (ICDs) while undergoing a pharmacological treatment for motor control dysfunctions with a dopamine agonist (DA). Conventional clinical interviews or questionnaires can be biased and may not accurately diagnose at the early stage. A wearable electroencephalogram (EEG)-sensing headset paired with an examination procedure can be a potential user-friendly method to explore ICD-related signatures that can detect its early signs and progression by reflecting brain activity. Methods A stereotypical Go/NoGo test that targets impulse inhibition was performed on 59 individuals, including healthy controls, patients with PD, and patients with PD diagnosed by ICDs. We conducted two Go/NoGo sessions before and after the DA-pharmacological treatment for the PD and ICD groups. A low-cost LEGO-like EEG headset was used to record concurrent EEG signals. Then, we used the event-related potential (ERP) analytical framework to explore ICD-related EEG abnormalities after DA treatment. Results After the DA treatment, only the ICD-diagnosed PD patients made more behavioral errors and tended to exhibit the deterioration for the NoGo N2 and P3 peak amplitudes at fronto-central electrodes in contrast to the HC and PD groups. Particularly, the extent of the diminished NoGo-N2 amplitude was prone to be modulated by the ICD scores at Fz with marginal statistical significance (r = − 0.34, p = 0.07). Conclusions The low-cost LEGO-like EEG headset successfully captured ERP waveforms and objectively assessed ICD in patients with PD undergoing DA treatment. This objective neuro-evidence could provide complementary information to conventional clinical scales used to diagnose ICD adverse effects. |
| Databáze: | OpenAIRE |
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