Large Neglected Ulcerated Melanoma Mimicking Extramedullary Plasmacytoma
| Autor: | Michael V Frost, Larisa M. Lehmer, Bruce D. Ragsdale, Kevin L Ferguson |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Pathology
medicine.medical_specialty Skin Neoplasms Anemia Biopsy Plasma Cells Elbow Breast Neoplasms Dermatology Pathology and Forensic Medicine Fatal Outcome Predictive Value of Tests hemic and lymphatic diseases Skin Ulcer Plasma Cell Myeloma Biomarkers Tumor medicine Humans Diagnostic Errors Amelanotic melanoma medicine.diagnostic_test business.industry Melanoma Melanoma Amelanotic General Medicine Middle Aged Flow Cytometry medicine.disease Immunohistochemistry medicine.anatomical_structure Plasmacytoma Female Chronic Inflammatory Infiltrate Multiple Myeloma business |
| Zdroj: | The American Journal of Dermatopathology. 33:e94-e98 |
| ISSN: | 0193-1091 |
| DOI: | 10.1097/dad.0b013e318221ba3c |
| Popis: | Amelanotic melanoma, a renowned impersonator, has taken on a new persona. A 63-year-old woman was seen in the emergency room with a chief complaint of back pain after a fall and was discovered to have a 15-cm fungating mottled gray mass independent of bone on the right elbow. Initial workup discovered lytic calvarial lesions, anemia (Hb 7; Hct 20%), and circulating plasma cells consistent with plasma cell myeloma. Biopsy of the elbow mass displayed sheets of plasmacytoid cells, some reactive for CD138. Flow cytometry revealed a substantial portion of the plasma cells in the tumor that were kappa restricted consistent with cutaneous plasmacytoma. The elbow mass was initially signed out as extramedullary involvement by her myeloma. Reevaluation of the mass after the patient experienced an explosive growth of multinodular jet black malignant melanoma on ipsilateral breast revealed MART-1 and S-100 reactivity of the majority of the cells. In retrospect, the elbow mass was a neglected primary amelanotic malignant melanoma with neoplastic plasma cells participating in its chronic inflammatory infiltrate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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