Normal karyotype acute myeloid leukemia with the CD7+ CD15+ CD34+ HLA-DR + immunophenotype is a clinically distinct entity with a favorable outcome
Autor: | Yukio Kobayashi, Hisashi Sakamaki, Masatomo Takahashi, Masafumi Taniwaki, Shunichiro Yamaguchi, Shuichi Miyawaki, Norio Asou, Shigeki Ohtake, Noriyoshi Iriyama, Tomoya Maeda, Yasushi Miyazaki, Sumihisa Honda, Yoshihiro Hatta, Tomoki Naoe, Toru Sakura, Shinya Sato, Kazunori Ohnishi, Tomohiko Taki, Hiroshi Handa |
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Rok vydání: | 2013 |
Předmět: |
Male
Myeloid Antigens CD34 Antigens CD7 Kaplan-Meier Estimate Leukocyte Count Immunophenotyping hemic and lymphatic diseases CEBPA Multicenter Studies as Topic Randomized Controlled Trials as Topic education.field_of_study Hematology Cytarabine Myeloid leukemia General Medicine Middle Aged Fucosyltransferases Leukemia Leukemia Myeloid Acute medicine.anatomical_structure Treatment Outcome Female medicine.drug Adult medicine.medical_specialty Antimetabolites Antineoplastic Adolescent Population Karyotype Lewis X Antigen Risk Assessment Young Adult Internal medicine medicine Humans education neoplasms Aged Proportional Hazards Models Retrospective Studies business.industry HLA-DR Antigens medicine.disease Karyotyping Cancer research CCAAT-Enhancer-Binding Proteins business |
Zdroj: | Annals of hematology. 93(6) |
ISSN: | 1432-0584 |
Popis: | Recently, the presence of CEBPA mutation was identified as an important prognostic factor for normal karyotype (NK) acute myeloid leukemia (AML). Because AML with CEBPA mutation is closely associated with CD7, CD15, CD34, and HLA-DR expression, we investigated the prognostic implications of CD7+ CD15+ CD34+ HLA-DR + immunophenotype in NK-AML. We analyzed the immunophenotype of 329 patients with NK-AML from the Japan Adult Leukemia Study Group (JALSG) AML97 population. NK-AML with the CD7+ CD15+ CD34+ HLA-DR + immunophenotype was classified as the CEBPA type, and NK-AML that did not meet this criterion was considered as the non-CEBPA type. The influence of the CEBPA status on event-free survival (EFS) and overall survival (OS) was assessed using log-rank test and a multivariate Cox proportional hazard regression model. Furthermore, the surface antigen expression profile in AML according to the CEBPA mutation status (monoallelic or biallelic) was also investigated. Of the 329 NK-AML patients that were studied, 39 and 243 were classified as having CEBPA and non-CEBPA type NK-AML, respectively. Patients with CEBPA type NK-AML had significantly better EFS and OS than those with non-CEBPA type NK-AML. Multivariate analysis showed that the CEBPA type and white blood cell (WBC) counts of >20 × 109/L were independent prognostic factors for EFS and OS. Moreover, NK-AML with the biallelic CEBPA mutation was more closely associated with CD34 positivity than that with the monoallelic CEBPA mutation. NK-AML with the CD7+ CD15+ CD34+ HLA-DR + immunophenotype is a clinically discrete entity, and this may have a possible role in risk stratification. |
Databáze: | OpenAIRE |
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