Variability in Fitness Effects Can Preclude Selection of the Fittest
| Autor: | Christopher J. Graves, Daniel M. Weinreich |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Genetics Natural selection Ecology Fitness landscape Survival of the fittest Inclusive fitness Robustness (evolution) Biology Article Genetic load Evolvability 03 medical and health sciences 030104 developmental biology Group selection Evolutionary biology Ecology Evolution Behavior and Systematics |
| Zdroj: | Annual Review of Ecology, Evolution, and Systematics. 48:399-417 |
| ISSN: | 1545-2069 1543-592X |
| DOI: | 10.1146/annurev-ecolsys-110316-022722 |
| Popis: | Evolutionary biologists often predict the outcome of natural selection on an allele by measuring its effects on lifetime survival and reproduction of individual carriers. However, alleles affecting traits like sex, evolvability, and cooperation can cause fitness effects that depend heavily on differences in the environmental, social, and genetic context of individuals carrying the allele. This variability makes it difficult to summarize the evolutionary fate of an allele solely on the basis of its effects on any one individual. Attempts to average over this variability can sometimes salvage the concept of fitness. In other cases, evolutionary outcomes can be predicted only by considering the entire genealogy of an allele, thus limiting the utility of individual fitness altogether. We describe a number of intriguing new evolutionary phenomena that have emerged in studies that explicitly model long-term lineage dynamics and discuss implications for the evolution of infectious diseases. |
| Databáze: | OpenAIRE |
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