Rapid fabrication and screening of tailored functional 3D biomaterials

Autor: Anthony Callanan, Robert Wallace, Antonio Conde-González, Deepanjalee Dutta, Mark Bradley
Rok vydání: 2019
Předmět:
Polymers
Biocompatible Materials
02 engineering and technology
01 natural sciences
in vitro bone model
Materials Testing
Cytoskeleton
Oligonucleotide Array Sequence Analysis
chemistry.chemical_classification
Tissue Scaffolds
Biomaterial
Sarcoma
Polymer
021001 nanoscience & nanotechnology
Condensed Matter Physics
Pores
Mechanics of Materials
Printing
Three-Dimensional
0210 nano-technology
Porosity
Pore size
Materials science
Fabrication
Biocompatibility
Cell Survival
Bioengineering
Nanotechnology
High-throughput
010402 general chemistry
Bone and Bones
Biomaterials
Materials Science(all)
Biological property
Cell Line
Tumor
Animals
Humans
Scaffolds
Tissue Engineering
Mechanical Engineering
X-Ray Microtomography
0104 chemical sciences
chemistry
Physical space
Microscopy
Electron
Scanning
Solvents
3D biomaterials
Stress
Mechanical
Zdroj: Conde-González, A, Dutta, D, Wallace, R, Callanan, A & Bradley, M 2020, ' Rapid fabrication and screening of tailored functional 3D biomaterials ', Materials Science and Engineering: C, vol. 108, 110489 . https://doi.org/10.1016/j.msec.2019.110489
ISSN: 1873-0191
DOI: 10.1016/j.msec.2019.110489
Popis: Three dimensional synthetic polymer scaffolds have remarkable chemical and mechanical tunability in addition to biocompatibility. However, the chemical and physical space is vast in view of the number of variables that can be altered e.g. chemical composition, porosity, pore size and mechanical properties to name but a few. Here, we report the development of an array of 3D polymer scaffolds, whereby the physical and chemical properties of the polymer substrates were controlled, characterized in parallel (e.g. micro-CT scanning of 24 samples) and biological properties screened. This approach allowed the screening of 48 different polymer scaffolds constructed in situ by means of freeze-casting and photo-polymerisation with the tunable composition and 3D architecture of the polymer scaffolds facilitating the identification of optimal 3D biomaterials. As a proof of concept, the array approach was used to identify 3D polymers that were capable of supporting cell growth while controlling their behaviour. Sitting alongside classical polymer microarray technology, this novel platform reduces the gap between the identification of a biomaterial in 2D and its subsequent 3D application.
Databáze: OpenAIRE
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