Cognitive Change during the Life Course and Leukocyte Telomere Length in Late Middle-Aged Men
| Autor: | Birgitte Fagerlund, Maria Harbo, Lene Rask, Erik Lykke Mortensen, Martin Lauritzen, Merete Osler, Laila Bendix |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Gerontology Cognitive Neuroscience lcsh:RC321-571 birth cohort study 03 medical and health sciences 0302 clinical medicine cognitive function telomere length mental health birth cohort study aging alzheimers-disease pulse pressure decline mortality dementia midlife metaanalysis association ability Geriatrics & Gerontology Neurosciences & Neurology telomere length Effects of sleep deprivation on cognitive performance Cognitive decline lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Depression (differential diagnoses) cognitive function Original Research Incidence (epidemiology) Confounding aging Cognition 030104 developmental biology Life course approach Psychology Body mass index 030217 neurology & neurosurgery mental health Demography Neuroscience |
| Zdroj: | Rask, L, Bendix, L, Harbo, M, Fagerlund, B, Mortensen, E L, Lauritzen, M J & Osler, M 2016, ' Cognitive Change during the Life Course and Leukocyte Telomere Length in Late Middle-Aged Men ', Frontiers in Aging Neuroscience, vol. 8, 300 . https://doi.org/10.3389/fnagi.2016.00300 Frontiers in Aging Neuroscience Rask, L, Bendix, L, Harbo, M, Fagerlund, B, Mortensen, E L, Lauritzen, M J & Osler, M 2016, ' Cognitive Change during the Life Course and Leukocyte Telomere Length in Late Middle-Aged Men ', Frontiers in Aging Neuroscience, vol. 8, no. DEC, 300 . https://doi.org/10.3389/fnagi.2016.00300 Frontiers in Aging Neuroscience, Vol 8 (2016) |
| ISSN: | 1663-4365 |
| DOI: | 10.3389/fnagi.2016.00300 |
| Popis: | Importance: Cognitive skills are known to decline through the lifespan with large individual differences. The molecular mechanisms for this decline are incompletely understood. Although leukocyte telomere length provides an index of cellular age that predicts the incidence of age-related diseases, it is unclear whether there is an association between cognitive decline and leukocyte telomere length.Objective: To examine the association between changes in cognitive function during adult life and leukocyte telomere length after adjusting for confounding factors such as education, mental health and life style.Design, Setting, and Participants: Two groups of men with negative (n = 97) and positive (n = 93) change in cognitive performance were selected from a birth cohort of 1985 Danish men born in 1953. Cognitive performance of each individual was assessed at age ~20 and 56 years. Leukocyte telomere length at age ~58 was measured using qPCR. Linear regression models were used to investigate the association between cognitive function and leukocyte telomere length.Results: Men with negative change in cognitive performance during adult life had significantly shorter mean leukocyte telomere length than men with positive change in cognitive performance (unadjusted difference β = −0.09, 95% CI −0.16 to −0.02, p = 0.02). This association remained significant after adjusting for smoking, alcohol consumption, leisure time activity, body mass index (BMI) and cholesterol (adjusted difference β = −0.09, 95% CI −0.17 to −0.01, p = 0.02) but was non-significant after adjusting for smoking, alcohol consumption, leisure time activity, BMI, cholesterol, current cognitive function, depression and education (adjusted difference β = −0.07, 95% CI −0.16 to −0.01, p = 0.08).Conclusion and Relevance: Preclinical cognitive changes may be associated with leukocyte telomere length. |
| Databáze: | OpenAIRE |
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