Carbon-dot-supported atomically dispersed gold as a mitochondrial oxidative stress amplifier for cancer treatment
| Autor: | Tingbin Zhang, Xiao’ai Chen, Jie Yu, Ningqiang Gong, Huaidong Jiang, Xing-Jie Liang, Xucong Teng, Xiaowei Ma, Yaling Gan, Shengkun Yao, Xiaoli Tan, Xixue Hu, Shuaidong Huo, Qunfang Zhou, Shizhu Chen, Xiaoxia Ye, Jinghong Li |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Biomedical Engineering
Metal Nanoparticles Mice Nude Antineoplastic Agents Apoptosis Bioengineering 02 engineering and technology Mitochondrion 010402 general chemistry medicine.disease_cause 01 natural sciences Cinnamaldehyde chemistry.chemical_compound In vivo Cell Line Tumor Neoplasms medicine Animals Humans General Materials Science Electrical and Electronic Engineering chemistry.chemical_classification Mice Inbred BALB C Reactive oxygen species Cell Death Glutathione 021001 nanoscience & nanotechnology Condensed Matter Physics Xenograft Model Antitumor Assays Carbon Atomic and Molecular Physics and Optics Mitochondria 0104 chemical sciences Cell biology Oxidative Stress chemistry Cancer cell Female Gold Reactive Oxygen Species 0210 nano-technology Oxidative stress |
| Zdroj: | Nature Nanotechnology. 14:379-387 |
| ISSN: | 1748-3395 1748-3387 |
| Popis: | Mitochondrial redox homeostasis, the balance between reactive oxygen species and antioxidants such as glutathione, plays critical roles in many biological processes, including biosynthesis and apoptosis, and thus is a potential target for cancer treatment. Here, we report a mitochondrial oxidative stress amplifier, MitoCAT-g, which consists of carbon-dot-supported atomically dispersed gold (CAT-g) with further surface modifications of triphenylphosphine and cinnamaldehyde. We find that the MitoCAT-g particles specifically target mitochondria and deplete mitochondrial glutathione with atomic economy, thus amplifying the reactive oxygen species damage caused by cinnamaldehyde and finally leading to apoptosis in cancer cells. We show that imaging-guided interventional injection of these particles potently inhibits tumour growth in subcutaneous and orthotopic patient-derived xenograft hepatocellular carcinoma models without adverse effects. Our study demonstrates that MitoCAT-g amplifies the oxidative stress in mitochondria and suppresses tumour growth in vivo, representing a promising agent for anticancer applications. |
| Databáze: | OpenAIRE |
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