Randomized Comparison of Selective Internal Radiotherapy (SIRT) Versus Drug-Eluting Bead Transarterial Chemoembolization (DEB-TACE) for the Treatment of Hepatocellular Carcinoma
| Autor: | Waltraud Eichhorn, Roman Kloeckner, Christian Ruckes, Gerd Otto, Gesine M. Wirth, Christoph Dueber, Michael B. Pitton, Mathias Schreckenberger, Peter R. Galle, Arndt Weinmann, Marcus A. Wörns |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Oncology
Male medicine.medical_specialty Radiation induced liver disease (RILD) Carcinoma Hepatocellular medicine.medical_treatment Treatment outcome Brachytherapy Pilot Projects Drug-eluting bead-transarterial chemoembolization (DEB-TACE) Internal medicine medicine Carcinoma Humans Radiology Nuclear Medicine and imaging Clinical Investigation Prospective Studies Chemoembolization Therapeutic neoplasms Aged Aged 80 and over Drug Carriers Deb tace Drug eluting beads business.industry Liver Neoplasms Middle Aged medicine.disease digestive system diseases Surgery Radiation therapy Treatment Outcome Radiology Nuclear Medicine and imaging Hepatocellular carcinoma Liver cirrhosis Selective internal radiotherapy (SIRT) Female business Cardiology and Cardiovascular Medicine |
| Zdroj: | Cardiovascular and Interventional Radiology |
| ISSN: | 1432-086X 0174-1551 |
| Popis: | Purpose To prospectively compare SIRT and DEB-TACE for treating hepatocellular carcinoma (HCC). Methods From 04/2010–07/2012, 24 patients with histologically proven unresectable N0, M0 HCCs were randomized 1:1 to receive SIRT or DEB-TACE. SIRT could be repeated once in case of recurrence; while, TACE was repeated every 6 weeks until no viable tumor tissue was detected by MRI or contraindications prohibited further treatment. Patients were followed-up by MRI every 3 months; the final evaluation was 05/2013. Results Both groups were comparable in demographics (SIRT: 8males/4females, mean age 72 ± 7 years; TACE: 10males/2females, mean age 71 ± 9 years), initial tumor load (1 patient ≥25 % in each group), and BCLC (Barcelona Clinic Liver Cancer) stage (SIRT: 12×B; TACE 1×A, 11×B). Median progression-free survival (PFS) was 180 days for SIRT versus 216 days for TACE patients (p = 0.6193) with a median TTP of 371 days versus 336 days, respectively (p = 0.5764). Median OS was 592 days for SIRT versus 788 days for TACE patients (p = 0.9271). Seven patients died in each group. Causes of death were liver failure (n = 4 SIRT group), tumor progression (n = 4 TACE group), cardiovascular events, and inconclusive (n = 1 in each group). Conclusions No significant differences were found in median PFS, OS, and TTP. The lower rate of tumor progression in the SIRT group was nullified by a greater incidence of liver failure. This pilot study is the first prospective randomized trial comparing SIRT and TACE for treating HCC, and results can be used for sample size calculations of future studies. |
| Databáze: | OpenAIRE |
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