STAT4 confers risk for rheumatoid arthritis and systemic lupus erythematosus in Mexican patients
| Autor: | J. F. Mendoza Rincón, J. Ramírez Bello, O. Beltrán Ramírez, I. Alemán Ávila, R. E. Barbosa Cobos |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male Risk Genotype Immunology DNA Mutational Analysis Polymorphism Single Nucleotide Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Sex Factors immune system diseases medicine Immunology and Allergy Humans Lupus Erythematosus Systemic Genetic Predisposition to Disease skin and connective tissue diseases Genotyping STAT4 Mexico 030203 arthritis & rheumatology business.industry Middle Aged STAT4 Transcription Factor medicine.disease Mexican population 030104 developmental biology Rheumatoid arthritis Female business |
| Zdroj: | Immunology letters. 175 |
| ISSN: | 1879-0542 |
| Popis: | STAT4 has been consistently associated with several autoimmune diseases, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The aim of this study was to determine whether the STAT4 rs7574865G/T polymorphism confers susceptibility for RA and SLE in a sample of Mexican patients. This study included 869 individuals: 415 patients with RA, 128 patients with SLE, and 326 controls. Genotyping using TaqMan probes showed an association between the STAT4 rs7574865G/T polymorphism and RA (GG vs. TT: OR 1.99, p=0.0009; G vs. T: OR 1.42, p=0.0009) and SLE (GG vs. TT: OR 2.98, 0.0003; G vs. T: OR 1.74, p=0.0002). Gender stratification showed an association with RA (GG vs. TT: OR 1.99, 95% CI 1.3-3.1, p=0.002; G vs. T: OR 1.42, 95% CI 1.1-1.8, p=0.002) and SLE (GG vs. TT: OR 3.3, 95% CI 1.7-6.2, p=0.0002; G vs. T: OR 1.8, 95% CI 1.3-2.4, p=0.0002) in women. Thus, the STAT4 rs7574865G/T polymorphism confers risk for RA and SLE in the Mexican population. |
| Databáze: | OpenAIRE |
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