In Vivo Measurements of Prelamina and Lamina Cribrosa Biomechanical Properties in Humans
| Autor: | Liang Zhang, Tin Aung, Tin A. Tun, Nicholas G. Strouthidis, Shamira A. Perera, Meghna R. Beotra, Craig Boote, Michael J A Girard, Mani Baskaran, Xiaofei Wang |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Intraocular pressure medicine.medical_specialty Open angle glaucoma genetic structures 0206 medical engineering Optic Disk Optic disk Glaucoma ocular biomechanics 02 engineering and technology Cribriform plate 03 medical and health sciences Tonometry Ocular Young Adult 0302 clinical medicine Optical coherence tomography In vivo Ophthalmology Optic Nerve Diseases medicine Humans tissue stiffness Intraocular Pressure Aged medicine.diagnostic_test business.industry optic nerve head Middle Aged medicine.disease 020601 biomedical engineering eye diseases Elasticity Healthy Volunteers Biomechanical Phenomena 030221 ophthalmology & optometry Optic nerve Female Ocular Hypertension sense organs Visual Fields business Glaucoma Angle-Closure Glaucoma Open-Angle Tomography Optical Coherence |
| Zdroj: | Investigative Ophthalmology & Visual Science |
| ISSN: | 1552-5783 0146-0404 |
| Popis: | Purpose: To develop and use a custom virtual fields method (VFM) to assess the biomechanical properties of human prelamina and lamina cribrosa (LC) in vivo.\ud \ud Methods: Clinical data of 20 healthy, 20 ocular hypertensive (OHT), 20 primary open-angle glaucoma, and 16 primary angle-closure glaucoma eyes were analyzed. For each eye, the intraocular pressure (IOP) and optical coherence tomography (OCT) images of the optic nerve head (ONH) were acquired at the normal state and after acute IOP elevation. The IOP-induced deformation of the ONH was obtained from the OCT volumes using a three-dimensional tracking algorithm and fed into the VFM to extract the biomechanical properties of the prelamina and the LC in vivo. Statistical measurements and P values from the Mann-Whitney-Wilcoxon tests were reported.\ud \ud Results: The average shear moduli of the prelamina and the LC were 64.2 ± 36.1 kPa and 73.1 ± 46.9 kPa, respectively. The shear moduli of the prelamina of healthy subjects were significantly lower than those of the OHT subjects. Comparisons between healthy and glaucoma subjects could not be made robustly due to a small sample size.\ud \ud Conclusions: We have developed a methodology to assess the biomechanical properties of human ONH tissues in vivo and provide preliminary comparisons in healthy and OHT subjects. Our proposed methodology may be of interest for glaucoma management. |
| Databáze: | OpenAIRE |
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