Probabilistic reversal learning under acute tryptophan depletion in healthy humans: a conventional analysis
| Autor: | Barbara J. Sahakian, Annemieke M. Apergis-Schoute, Rudolf N. Cardinal, Robyn Yellowlees, Trevor W. Robbins, Frederique E. Arntz, Annabel Price, David M Christmas, Jonathan W. Kanen |
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| Přispěvatelé: | Kanen, Jonathan W. [0000-0002-4095-5405], Cardinal, Rudolf [0000-0002-8751-5167], Price, Annabel [0000-0002-5505-5231], Sahakian, Barbara [0000-0001-7352-1745], Robbins, Trevor [0000-0003-0642-5977], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Serotonin Serotonin synthesis Conventional analysis tryptophan depletion Reversal Learning Feedback 03 medical and health sciences 0302 clinical medicine Internal medicine Negative feedback Healthy volunteers medicine Enhanced sensitivity Humans Pharmacology (medical) Null Results in Brief Pharmacology probabilistic reversal learning business.industry Tryptophan Serotonin reuptake 030227 psychiatry Psychiatry and Mental health Endocrinology Sample Size Female business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Psychopharmacology (Oxford, England) |
| ISSN: | 1461-7285 0269-8811 |
| Popis: | The involvement of serotonin in responses to negative feedback is well established. Acute serotonin reuptake inhibition has enhanced sensitivity to negative feedback (SNF), modelled by behaviour in probabilistic reversal learning (PRL) paradigms. Whilst experiments employing acute tryptophan depletion (ATD) in humans, to reduce serotonin synthesis, have shown no clear effect on SNF, sample sizes have been small. We studied a large sample of healthy volunteers, male and female, and found ATD had no effect on core behavioural measures in PRL. These results indicate that ATD effects can differ from other manipulations of serotonin expected to have a parallel or opposing action. |
| Databáze: | OpenAIRE |
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