Klotho and Endothelin-1 in Pseudoexfoliation Syndrome and Glaucoma
| Autor: | Ali Kiavar, Mohammad Hosein Ahoor, Rana Sorkhabi, Amir Ghorbanihaghjo |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Intraocular pressure Aging Pseudoexfoliation syndrome Glaucoma Aqueous humor Enzyme-Linked Immunosorbent Assay Exfoliation Syndrome Aqueous Humor 03 medical and health sciences 0302 clinical medicine Internal medicine PEG ratio medicine Humans Klotho Klotho Proteins Intraocular Pressure Aged Glucuronidase Endothelin-1 business.industry Significant difference Middle Aged medicine.disease Endothelin 1 Ophthalmology 030104 developmental biology Endocrinology Cross-Sectional Studies 030221 ophthalmology & optometry Female business human activities Biomarkers |
| Zdroj: | Journal of glaucoma. 25(12) |
| ISSN: | 1536-481X |
| Popis: | Purpose Klotho is a newly discovered protein that presumably has an important role in the aging process. The goal of this research is to compare the levels of Klotho and Endothelin-1 (ET-1) in the serum and aqueous humor of patients with pseudoexfoliation syndrome (PES) and pseudoexfoliative glaucoma (PEG). Patients and methods Aqueous humor and serum samples were obtained at the time of cataract surgery from 15 patients with PES, 15 patients with PEG, and 15 control patients. All of the samples were analyzed using enzyme-linked immunosorbent assay to evaluate the levels of ET-1 and Klotho protein. Result Aqueous and serum levels of Klotho in PES patients (49.02±10.97, 56.32±10.25 ng/mL) and PEG patients (34.53±4.87, 50.49±2.63 ng/mL) were lower than in control patients (56.31±7.68, 65.06±12.32 ng/mL). Both aqueous and serum levels of Klotho in the PEG group were lower than in the PES group (P=0.001). Mean aqueous and serum levels of ET-1 in the PES (1.28±0.09, 1.65±0.75 pg/mL) and the PEG groups (1.45±0.07, 1.58±0.58 pg/mL) were significantly higher than that measured in the control group (1.17±0.09, 1.16±0.34 pg/mL). Aqueous levels of ET-1 in the PEG group were higher than the PES group (P=0.04), but there were no significant difference in serum levels of ET-1 between the PES and the PEG groups (P=0.83). Conclusions Aqueous and serum levels of Klotho decreased both in PES and PEG patients, and this decrease in the PEG group was more significant. In contrast, aqueous and serum levels of ET-1 increased in the PES and the PEG patients, and the increase in the aqueous level of ET-1 in PEG patients was more significant. |
| Databáze: | OpenAIRE |
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