Electroacupuncture Potentiates the Antiallodynic Effect of Intrathecal Neostigmine in a Rat Model of Neuropathic Pain
| Autor: | Sungtae Koo, Boram Sun, Sun Kwang Kim, Byung-Il Min, Jung Hyuk Park, Hyunsu Bae, Ha Neul Kim, Sun Mi Choi |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Physiology business.industry Electroacupuncture medicine.medical_treatment Rat model Intrathecal Combined Modality Therapy Neostigmine Rats Rats Sprague-Dawley Disease Models Animal Allodynia Anesthesia Neuropathic pain medicine Animals Neuralgia Cholinesterase Inhibitors medicine.symptom business Injections Spinal medicine.drug |
| Zdroj: | The Journal of Physiological Sciences. 58:357-360 |
| ISSN: | 1880-6562 1880-6546 |
| DOI: | 10.2170/physiolsci.sc008308 |
| Popis: | This study was performed to examine whether electroacupuncture potentiates the neostigmine-induced antiallodynia in neuropathic pain rats. Although intrathecal neostigmine (0.05, 0.1, and 0.3 microg) dose-dependently relieved cold allodynia, 0.3 microg neostigmine caused side effects. The coapplication of 0.1 microg neostigmine and electroacupuncture, however, produced potent antiallodynia, which was parallel to the effect of 0.3 microg neostigmine, without side effects. These results indicate that electroacupuncture can enhance the antiallodynic action of intrathecal neostigmine. |
| Databáze: | OpenAIRE |
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