Risk factors of hepatic function alterations in hospitalized adult patients treated with short-term parenteral nutrition receiving the same lipid composition at the same dose

Autor: Toni Lozano-Andreu, J. Llop-Talaveron, Maria B. Badia-Tahull, Elisabet Leiva-Badosa, Ana Suárez-Lledó
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
medicine.medical_specialty
Bilirubin
Endocrinology
Diabetes and Metabolism
Clinical Biochemistry
Clinical nutrition
Gastroenterology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Liver Function Tests
Risk Factors
Internal medicine
medicine
Lipid emulsion
Humans
Risk factor
lcsh:RC620-627
Liver diseases
Parenteral Nutrition Solutions
030109 nutrition & dietetics
business.industry
Research
Malalties del fetge
Incidence (epidemiology)
Biochemistry (medical)
Cancer
Non-critical patient
Alanine Transaminase
gamma-Glutamyltransferase
medicine.disease
Parenteral nutrition
Liver tests
Hospitalization
Oxidative Stress
lcsh:Nutritional diseases. Deficiency diseases
Liver
Alimentació parenteral
chemistry
Parenteral feeding
Alkaline phosphatase
030211 gastroenterology & hepatology
business
Lipidology
Zdroj: Lipids in Health and Disease, Vol 17, Iss 1, Pp 1-9 (2018)
Dipòsit Digital de la UB
Universidad de Barcelona
Lipids in Health and Disease
Popis: Background: High doses and vegetable origin of lipid emulsions (LE) are prominent factors for liver test (LT) alterations in patients treated with parenteral nutrition (PN). This study aims to determine incidence of LT alterations, and risk factors related to these alterations in patients with short term PN with homogenous LE. Methods: Adult non-critically ill hospitalized patients, with normal LTs at the beginning of PN, receiving 0.8 g/kg/day of an olive/soybean LE were included. A paired Student t-test was applied to compare final with initial LT values. LT variation (end vs start of PN) according to type of surgery and infection was studied by means of an analysis of the variance. Univariate and multivariate analyses were constructed to relate the variations of each of the 4 LTs with the adjustment variables. Results: One hundred eighty one patients (66.57 ± 12.89 years; 72.4% men), 66.8% suffered from cancer. Final LT values increased from initial values for gamma-glutamyltransferase (GGT) 2.69 ± 2.49 μkat/L vs 0.55 ± 0.36 μkat/L, alkaline phosphatase (AP) 1.97 ± 1.49 μkat/L vs 1.04 ± 0.33 μkat/L, and alanine aminotransferase (ALT) 0.57 ± 0. 92 μkat/L vs 0.32 ± 0.26 μkat/L. GGT and AP variations were associated with days of PN; GGT, AP and total bilirubin with surgical patients, AP variations with infection, and GGT with cancer. Multivariate analysis: elevation of GGT, AP and ALT was related to infection, days of PN and surgery. Conclusions: Factors that increased the risk of LTs elevation during short term PN treatment were duration of PN, surgery, cancer, and infection associated with oxidative stress.
Databáze: OpenAIRE
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