Carboxyl-, sulfonyl-, and phosphate-terminal dendrimers as a nanoplatform with lymph node targeting
| Autor: | Chie Kojima, Mikako Ogawa, Yuji Kuge, Tatsumi Sato, Takayuki Ohira, Shu Nagashima, Jyoji Yamate, Kohei Nakajima, Takeshi Izawa, Kei Higashikawa, Yutaka Nishimoto |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Dendrimers
Injections Intradermal medicine.medical_treatment Drug Compounding Pharmaceutical Science 02 engineering and technology 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Immune system Dendrimer medicine Animals Tissue Distribution Phosphorylation Lymph node Fluorescent Dyes Sulfonyl chemistry.chemical_classification Drug Carriers Mice Inbred BALB C Chemistry Optical Imaging Cancer Immunotherapy 021001 nanoscience & nanotechnology medicine.disease medicine.anatomical_structure Drug delivery Cancer research Nanoparticles Female Lymph Lymph Nodes 0210 nano-technology |
| Zdroj: | International journal of pharmaceutics. 576 |
| ISSN: | 1873-3476 |
| Popis: | The development of drug delivery vehicles to cancer and/or immune cells in lymph nodes is important for cancer diagnosis, therapy, and immunotherapy. We previously reported that anionic carboxyl-terminal dendrimers were accumulated in lymph nodes. In this study, three anionic dendrimers with carboxyl-, sulfonyl-, and phosphate-terminal groups were prepared to examine the lymph node targeting and the association with immune cells in the lymph nodes. These anionic dendrimers were accumulated in the lymph node by intradermal injection. Although the carboxyl- and sulfonyl-terminal dendrimers were diffused from the injection site, the phosphate-terminal dendrimers were mostly retained. The phosphate-terminal dendrimer was recognized by the macrophages, dendritic cells, and B cells in the lymph node, whereas the carboxyl- and sulfonyl-terminal dendrimers were not. Our results show that these anionic dendrimers were accumulated in the lymph node where the association with immune cells could be controlled by the terminal structure of the dendrimer. The phosphate-terminal dendrimer can be used as a nanoplatform for the delivery of some bioactive molecules to some immune cells, including B cells, in the lymph node. |
| Databáze: | OpenAIRE |
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