Acute corneal endothelial graft rejection following COVID-19 vaccination
| Autor: | A. Saad, G. Cherfan, A. Crnej, Ziad Khoueir |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Graft Rejection
COVID-19 Vaccines medicine.medical_treatment medicine.disease_cause Corneal Diseases Corneal Transplantation Immune system Immune privilege medicine Humans Letter to the Editor Corneal transplantation SARS-CoV-2 business.industry Endothelium Corneal Graft Survival Vaccination COVID-19 Immune dysregulation medicine.disease Transplant rejection Endothelial stem cell Ophthalmology Immunization Immunology business Keratoplasty Penetrating |
| Zdroj: | Journal Francais D'Ophtalmologie |
| ISSN: | 0181-5512 |
| DOI: | 10.1016/j.jfo.2021.06.001 |
| Popis: | The current global health crisis is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), a novel epidemic strain of Betacoronavirus that is responsible for the viral pandemic, coronavirus disease 2019 (COVID-19). There are at present around 200 SARS-CoV-2 candidate vaccines in preclinical and clinical trials throughout the world. Within less than a year time some very promising COVID-19 vaccines were developed at an unprecedented speed and are now being deployed via emergency use authorization for immunization [1], [2]. Allogenic tissue or solid organ transplantations introduce genetically different tissues to the recipient, which typically causes a T cell mediated immune response that leads to rejection and destruction of the transplant [3]. Corneal transplantation has a low graft rejection rate because of ocular immune privilege, which can be compromised by increased immune dysregulation [4]. The risk of developing an immune reaction after Descemet membrane endothelial keratoplasty (DMEK) is considered to be very low and it has been reported to be from 0.5 to 5.3% [5], [6]. If diagnosed early, corneal endothelial transplant rejection is potentially reversible, albeit with endothelial cell loss [7]. To our knowledge, we report the first case of acute endothelial graft rejection after Descemet membrane endothelial keratoplasty (DMEK) occurring after the first dose of the BNT162b2 mRNA SARS-CoV-2 (BioNTech/Pfizer) vaccination. |
| Databáze: | OpenAIRE |
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