Differences in dopaminergic neuroprotective effects of estrogen during estrous cycle
| Autor: | Arani V. Pillai, Glenda E. Gillies, Hilary E. Murray, Krishna P. Datla, David T. Dexter |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
endocrine system
medicine.medical_specialty Free Radicals medicine.drug_class Dopamine Neurotoxins Estrous Cycle Nerve Tissue Proteins Substantia nigra Biology Ferric Compounds Neuroprotection Injections Chlorides Parkinsonian Disorders Internal medicine Basal ganglia medicine Animals Rats Wistar Oxidopamine reproductive and urinary physiology Dopamine transporter Estrous cycle Dopamine Plasma Membrane Transport Proteins Membrane Glycoproteins Estradiol urogenital system General Neuroscience Dopaminergic Membrane Transport Proteins Estrogens Homovanillic Acid Diestrus Rats Substantia Nigra Neuroprotective Agents Endocrinology nervous system Estrogen biology.protein 3 4-Dihydroxyphenylacetic Acid Female Proestrus hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | NeuroReport. 14:47-50 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-200301200-00009 |
| Popis: | Previous studies suggest that estrogen treatment protects nigrostriatal dopaminergic neurons, but have not examined whether the changes in estrogen levels during estrous cycle can influence the susceptibility of these neurons to neurotoxins. Here we show that the loss of dopaminergic neurons in the substantia nigra was greater in animals lesioned at diestrus (low estrogen) using 6-hydroxydopamine or buffered iron chloride, when compared with animals lesioned at proestrus (high estrogen). Lesioning at diestrus with 6-hydroxydopamine reduced the striatal dopamine content, whereas the dopamine content was preserved in animals lesioned at proestrus. The density of the dopamine transporter, upon which 6-hydroxydopamine toxicity is dependent, was lower when circulating estrogen was high. These results thus support a neuroprotectory role for estrogen. |
| Databáze: | OpenAIRE |
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